Ingredient intelligenceBotanical & plant materialsContent basis Limited human evidenceBotanical materialHigh-caution knowledge

St. John's Wort

St. John's Wort is documented here by identity, form, human-evidence context, and safety—not by marketing claims.

Also known as st johns wort · st john's wort · st. johns wort · Hypericum perforatum

  • Mood and stress response

Identity and form

St. John's wort is Hypericum perforatum aerial material or extract, often standardized to hypericin or hyperforin.

The label should identify the source, form, preparation, and active or marker amount when those details determine comparability.

What the evidence can answer

Human research has examined St. John's Wort in relation to mood and stress-response measures. The amount, source, preparation, population, comparator, and measured outcome determine whether a result applies to a finished product.

Current WQ evidence label: Limited human evidence. This label describes the present evidence context, not a promise of benefit.

Safety and decision context

High-caution knowledge. This substance has drug-like pharmacology or a drug/supplement boundary that requires specialist review. Serotonergic medicines and combinations require professional review. Pregnancy and breastfeeding safety is uncertain or specifically cautioned.

Review medicines, pregnancy or breastfeeding, allergies, medical history, and the complete finished label with a qualified professional when relevant.

How WQ connects this entry

WQ links this canonical identity to exact aliases, research topics, related ingredient forms, products with matching structured data, and articles that name the same entity. Related does not mean equivalent or recommended.

What it won't do

This guide does not establish disease treatment, prevention, or cure for St. John's Wort.

A related study, traditional use, or biochemical mechanism does not validate every commercial extract, dose, formula, or user context.

Common questions

What is St. John's Wort?

St. John's wort is Hypericum perforatum aerial material or extract, often standardized to hypericin or hyperforin.

What should be compared on a St. John's Wort label?

The label should identify the source, form, preparation, and active or marker amount when those details determine comparability.

Why is St. John's Wort shown with a risk label?

WQ assigns “High-caution knowledge” to preserve important safety or regulatory context. Inclusion is educational and does not imply availability, suitability, or endorsement.

References

This article is for general educational purposes and is not medical advice. These statements have not been evaluated by the Food and Drug Administration. Our products are not intended to diagnose, treat, cure, or prevent any disease.

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